PhenoRescue AI

structural × phenotypic × generative

no auth · single dashboard

1 · TP53 variant

2 · pipeline parameters

Generated molecules60

Score weighting α (structural)α 0.45 / β 0.55

Include known p53 reactivators

agent workflow

1Resolve variant annotation (NCI TP53 DB)
2Fold mutant DBD (ESMFold / AlphaFold)
3Generate scaffolds (GenMol · SAFE diffusion)
4Steer properties (MolMIM latent walk)
5Predict pose (DiffDock) + physics rescoring
6Phenotypic classifier (JUMP Cell Painting)
7Rank by Phenotypic Rescue Score

Select a variant and run the screen.